منابع مشابه
Practical management of pain in sickling disorders.
Sickle cell disease affects approximately 5000 people in the UK predominantly of African and Afro-Caribbean origin.1 The majority of those affected live in inner city areas; for example it is the most common inherited condition in the City and Hackney district of London. There is a high morbidity and mortality in children with up to 10% dying within the first 10 years of life.2 Sickle cell rela...
متن کاملExertional sickling: questions and controversy
Sickle cell trait (SCT) occurs in about 8% of African-Americans and is often described to be of little clinical consequence. Over time, a number of risks have emerged, and among these are rare but catastrophic episodes of sudden death in athletes and other individuals associated with physical activities which is often described as exercise collapse associated with sickle trait (ECAST). Despite ...
متن کاملMacular and perimacular vascular remodelling sickling haemoglobinopathies.
The posterior pole vasculature of 100 patients with different sickling haemoglobinopathies was studied prospectively over a period of three years. Various abnormalities of the posterior pole vasculature were seen in 29 per cent of the patients. Continuous remodelling of the macular and perimacular vasculature occurred. Visual acuity was variably affected and sometimes remained intact.
متن کاملThinking beyond sickling to better understand pain in sickle cell disease.
Painful vaso-occlusive crises (VOCs) are the hallmark of sickle cell disease (SCD); however, many patients experience frequent daily pain that does not follow the pattern of typical VOCs. This pain of variable severity, also referred as persistent pain in the SCD literature, contributes to significant morbidity and poor quality of life and often fails to respond adequately to standard SCD thera...
متن کاملErythrocyte sickling during exercise and thermal stress.
OBJECTIVE To examine effects of exercise in the heat and fluid intake on erythrocyte sickling and neutrophil activation in carriers of sickle cell trait (HbAS). DESIGN, SETTING, AND PARTICIPANTS Six African American men (2 HbAS; 42% HbS, 4 HbAA; 20.7 +/- 0.8 years; 87.4 +/- 9.6 kg) participated in 2 randomized sessions (separate days) each consisting of 45 minutes of brisk walking (treadmill)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1974
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5909.54